Diablo 2 - crash on startup

If you have been using Geforce Experience to manage your game settings for your various games. (This can be set in geforce experience to automatically optimized all new additions as the game is detected.) you can try adjusting down the settings. I do not know offhand what level of settings controls DLSS there but most folks say if they drop it down to the last or second to last point it should disable DLSS. From there you can stop geforce experience from automatically trying to optimize the game, launch the game normally and then adjust settings in game to get your preferred performance/quality setup. If that solves the issue, then you should be ok to play.

I have seen a few reports of DLSS related issues and performance problems so disabling it when possible is a good way to test. At that point it would be worth reporting the issue on the bug report forums to help our QA and Dev teams investigate potential issues with it and either work on the game or with Nvidia to try and address potential issues with it.